郭兴启，男，1963年10月生，山盾它断东嘉祥人。博士，教授，博士生导师。现任山东农业大学生命科学学院副院长，山东省生物化学与分子生物学学会常务理事。近之凯年来主持承担了国家自然科学基金、国家转基因植物研究专项、中国博士后科学基金、山东省中青年科学家来自科研奖励基金等多项亮自课题。在棉花和蜜蜂重要抗病抗逆基因的分离与功能分析、植物抗病基因工程等方面，均获得了许多拥有我国自主知识产权的360百科研究成果，获得国家发明专利6项。曾分成造势正燃粮东味获山东省科技进步二等奖、三等奖周燃各1项;获山东秋扩云院减值补领农业大学教学成甚德刘山片背载果一等奖3项、山东省教学成果二等奖、三等奖各1项。在《植物病理学报》、《中国科学》、《Jour渐社nal of Experi面修怀落哪马灯mental Botany》、《Plant Molecular Biology》、《FEBS Jo岁重架日丰宪印urnal》、《BMC Plant Biology》等国内外著名学术刊物上发表论文60余篇。曾为《Gene》、《Plant Biology》、《Journal of Insect Physiology》、《New Phytologist》等国际学术刊物审稿多篇。
- 中文名称 郭兴启
- 国籍 中国
- 出生日期 1963
- 职业 教授
- 性别 男
个人简介
郭兴启，男，1963年10月生，山东嘉祥人。博士，教授，博士生导师。现论好价走司极任山东农业大学生命科学学院副院长，山东省生物化学与分子生物学学会副理事长，生物技术国家级特色专业较记资建设项目负责人，生物技术与工程省级实验教学示范中心主任。获山东省教学成果二等奖1项(首位)、三等奖1项(首位)，山东省教学名师，山东省优秀研究生指导教师。验们二标京展树足处卷近年来主持承担过国家自然科学基金、国家转基因植物研究专项、农业部现代农业产业技术充肉基混体系建设专项等多项课题。多年来以重要经济作物棉花和特种来自经济动物蜜蜂为研究对象，从生物化学与分子生物学角度深入开米展了棉花和蜜蜂抗360百科病抗逆功能的研究，分离获得了多个拥有我国自主知识产权的重要抗病抗逆功能基因，阐明了部分基因的表达调控模式及信号转导通路，并对这些基因的生物学功能及应用潜质进行了深入广泛的判卷研究。近年来，已获得国家发明专利6项，在《病毒学报》、《Journal of Experimental Botany》、《Free Radical Biology and Medicine》、《Insect Biochemistry and Molecular Biology》、《Plant Molecular Biology》等信着国内外著名学术刊物上发表论文8远充调论另含0余篇。
教学工作
承担本木派井搞令实如黄慢困科生《分子生物学》、《基础生物化学实验》;硕士研究生《分子生物学》、《高级生物化学实验技术》;博士研究生《植物逆境信号转导与基践苏课合山学政力因工程》等课程的教学工作。
研究方向
1. 棉花抗病抗逆分子生物学
2. 中华蜜蜂抗病抗逆分子生物学
科研项目
1. 国频国轮家自然科学基金《棉来自花激酶GhMKK6基因的功能分析及其级联信号途经的鉴定》(No. 31471424)
2. 国家自然科学基金《棉花GhMPK7基因广谱抗病功能的分子机理研究》360百科(No. 31171837)
3. 国家自然科学基金《温度对RNA沉默的抑制及其分子机理研究》(No. 30370928)
4. 国家自然科学基金《RNA介导抗性转基因植物的抗病机制及遗传规律》(No. 30571215)
5. 中国博士后科学基金《转基因植物中RNA介导抗性的遗传学》(No. 2002031167)
6. 山东省中青年科学家科研奖励基金《抗病毒转基因植物释放项音品析的环境风险性研究》(No. 02BS025)
7. 国家转又胜始补胡项基因植物研究重大丝第底案渐专项《棉花高产性状激素调控基因的克隆和克隆新方法的研究》子课题(No. 2009ZX08009-113B)
8. 农业部现代农业产业技术体系建设专项《现代农业蜂产业技术体系建设》子课题(No. NY去CYTX-43)
发表论文
1. Yan Yan, Haihong Jia, Fang Wang振, Chen Wang, Shuchang 空细烈频队Liu, Xingqi Guo*. Overexpression of GhWRKY27a reduces tolerance to drought stres保式盐药失断首抓门班s and resistance to R民孙急hizoctonia solani infection i草n transgeni普沉采c Nicotiana benthamiana. Frontiers in Physiology, 201零但袁府友着必阿不5, 6: 265.
2. Xiaoqian Chu, Chen Wang掌载架参括云怎, Xiaobo Ch大既审烧没状概务en, Wenjing Lu, Han Li, Xiul写药很别帝府帮听ing Wang, Lili Hao, Xingqi Guo*. The cotton WRKY gene GhWRKY41 positively regulates salt and drought stress tolerance in transgenic Nicotiana benthamiana. PLoS ONE, 2015, 10(11): e0143022.
3. Xiaobo Chen, Ji Wang, Ming Zhu, Hailon巴应末食界天供击身g An, Dongdong Liu川, Lili Hao, Xingqi Guo*. A cotton Raf-like MAP3K gene, GhMAP3K40, mediates reduced tol制易艺声句儿erance to biotic and abiotic stress in Nicotiana benthamiana by negatively regulating growth and development. Plant Science, 2015, 240: 10-24.
4. Haihong Jia, Chen Wang, Fang Wang, Shuchang Liu, Guilin Li, Xingqi Guo*. GhWRKY68 reduces resistance to salt and drought in transgenic Nicotiana benthamiana. PLoS ONE, 2015, 10(3): e0120646.
5. Yifeng Huaxia, Fang Wang, Yan Yan, Feng Liu, Hongfang Wang, Xingqi Guo*, Baohua Xu. A novel 1-Cys thioredoxin peroxidase gene in Apis cerana cerana: characterization of AccTpx4 and its role in oxidative stresses. Cell Stress and Chaperones, 2015, 20(4): 663-672.
6. Xiaobo Chen, Pengbo Yao, Xiaoqian Chu, Lili Hao, Xingqi Guo*, Baohua Xu. Isolation of arginine kinase from Apis cerana cerana and its possible involvement in response to adverse stress. Cell Stress and Chaperones, 2015, 20(1): 169-183.
7. Huiru Yan, Haihong Jia, Xiaobo Chen, Lili Hao, Hailong An, Xingqi Guo*. The cotton WRKY transcription factor GhWRKY17 functions in drought and salt stress in transgenic Nicotiana benthamiana through ABA signaling and the modulation of reactive oxygen species production. Plant & Cell Physiology, 2014, 55(12),2060-2076.
8. Yan Yan, Yuanying Zhang, Yifeng Huaxia, XiulingWang, Pengbo Yao, Xingqi Guo*, Baohua Xu. Identification and characterisation of a novel 1-Cys thioredoxin peroxidase gene (AccTpx5) from Apis cerana cerana. Comparative Biochemistry and Physiology, Part B, 2014, 172-173: 39-48.
9. Weina Shi, Lili Hao, Jing Li, Dongdong Liu, Xingqi Guo*, Han Li. The Gossypium hirsutum WRKY gene GhWRKY39-1 promotes pathogen infection defense responses and mediates salt stress tolerance in transgenic Nicotiana benthamiana. Plant Cell Report, 2014, 33(3): 483-498.
10. Xiuling Wang, Yan Yan, Yuzhen Li, Xiaoqian Chu, Changai Wu, Xingqi Guo*. GhWRKY40, a multiple stress-responsive cotton WRKY gene, plays an important role in the wounding response and enhances susceptibility to ralstonia solanacearum infection in transgenic Nicotiana benthamiana. PLoS ONE, 2014, 9(4): e93577.
11. Yuzhen Li, Liang Zhang, Wenjing Lu, Xiuling Wang, Changai Wu,Xingqi Guo*. Overexpression of Cotton GhMKK4 enhances disease susceptibility and affects abscisic acid, gibberellin and hydrogen peroxide signalling in transgenic Nicotiana benthamiana. Molecular Plant Pathology, 2014, 15(1): 94-108.
12. Pengbo Yao, Xiaobo Chen, Yan Yan, Feng Liu, Yuanying Zhang, Xingqi Guo*, Baohua Xu. Glutaredoxin, glutaredoxin 2, thioredoxin 1 and thioredoxin peroxidase 3 play important roles in antioxidant defense in Apis cerana cerana. Free Radical Biology and Medicine, 2014, 68: 335-346.
13. Yuzhen Li, Liang Zhang, Xiuling Wang, Wei Zhang, Lili Hao, Xiaoqian Chu, Xingqi Guo*. Cotton GhMPK6a negatively regulates osmotic tolerance and bacterial infection in transgenic Nicotiana benthamiana, and plays a pivotal role in development. The FEBS Journal, 2013, 280: 5128-5144.
14. Wenjing Lu, Xiaoqian Chu, Yuzhen Li, Chen Wang, Xingqi Guo*. Cotton GhMKK1 induces the tolerance of salt and drought stress, and mediates defence responses to pathogen infection in transgenic Nicotiana benthamiana. PLoS ONE, 2013, 8(7): e68503.
15. Pengbo Yao, Lili Hao, Fang Wang, Xiaobo Chen, Yan Yan, Xingqi Guo*, Baohua Xu. Molecular cloning, expression and antioxidant characterisation of a typical thioredoxin gene (AccTrx2) in Apis cerana cerana. Gene, 2013, 527(1): 33-41.
16. Pengbo Yao, Wenjing Lu, Fei Meng, Xiuling Wang, Baohua Xu, Xingqi Guo*. Molecular cloning, expression and oxidative stress response of a mitochondrial thioredoxin peroxidase gene (AccTpx-3) from Apis cerana cerana. Journal of Insect Physiology, 2013, 59(3): 273-282.
17. Huiru Yan, Haihong Jia, Xiuling Wang, Hongru Gao, Xingqi Guo*, Baohua Xu. Identification and characterization of an Apisceranacerana Delta class glutathione S-transferase gene (AccGSTD) in response to thermal stress. Naturwissenschaften, 2013, 100(2): 153-163.
18. Yuanying Zhang, Huiru Yan, Wenjing Lu, Yuzhen Li, Xingqi Guo*, Baohua Xu. A novel Omega-class glutathione S-transferase gene in Apis cerana cerana: molecular characterisation of GSTO2 and its protective effects in oxidative stress. Cell Stress and Chaperones, 2013, 18(4): 503-516.
19. Huiru Yan, Haihong Jia, Hongru Gao, Xingqi Guo*, Baohua Xu. Identification, genomic organization, and oxidative stress response of a sigma class glutathione S-transferase gene (AccGSTS1) in the honey bee, Apis cerana cerana. Cell Stress and Chaperones, 2013, 18(4): 415-426.
20. Liang Zhang, Yuzhen Li , Wenjing Lu, Fei Meng, Changai Wu, Xingqi Guo*. Cotton GhMKK5 affects disease resistance, induces HR-like cell death, and reduces the tolerance to salt and drought stress in transgenic Nicotiana benthamiana. Journal of Experimental Botany, 2012, 63(10): 3935-3952.
21. Feifei Yu, Yifeng Huaxia, Wenjing Lu, Changai Wu, Xuecheng Cao, Xingqi Guo*. GhWRKY15, a member of the WRKY transcription factor family identified from cotton (Gossypium hirsutum L.), is involved in disease resistance and plant development. BMC Plant Biology, 2012, 12(1): 144.
22. Wang Mian, Li Shanwei, Yang Haifang, Gao Zheng, Wu Changai, Xingqi Guo*. Characterization and functional analysis of GhRDR6, a novel RDR6 gene from cotton (Gossypium hirsutum L.). Bioscience Reports, 2012, 22: 139-151.
23. Huiru Yan, Fei Meng, Haihong Jia, Xingqi Guo*, Baohua Xu. The identification and oxidative stress response of a zeta class glutathione S-transferase (GSTZ1) gene from Apis cerana cerana. Journal of Insect Physilology, 2012, 58(6): 782-791.
24. Fei Meng, Wenjing Lu, Feifei Yu, Minjiang Kang, Xingqi Guo*, Baohua Xu. Ribosomal protein L11 is related to brain maturation during the adult phase in Apis cerana cerana (Hymenoptera, Apidae). Naturwissenschaften, 2012, 99(2): 343-352.
25. Xiaoli Yu, Wenjing Lu, Rujiang Sun, Xingqi Guo*, Baohua Xu. Identification and characterization of a novel calcyclin binding protein (CacyBP) gene from Apis cerana cerana. Molecular Biology Reports, 2012, 39(8): 8053-8063.
26. Liang Zhang, Dongmei Xi, Shanwei Li, Zheng Gao, SL Zhao, Jing Shi, Changai Wu, Xingqi Guo*. A cotton group C MAP kinase gene, GhMPK2, positively regulates salt and drought tolerance in tobacco. Plant Molecular Biology, 2011, 77: 17-31.
27. Jing Shi, Liang Zhang, Hailong An, Changai Wu, Xingqi Guo*. GhMPK16, a novel stress-responsive group D MAPK gene from cotton, is involved in disease resistance and drought sensitivity. BMC Molecular Biology, 2011, 12: 22
28. Liang Zhang, Dongmei Xi, Lu Luo, Fei Meng, Yuzhen Li, Changai Wu, Xingqi Guo*. Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress. The FEBS Journal, 2011, 278(8): 1367-1378.
29. Xiaoli Yu, Mian Wang, Minjiang Kang, Li Liu, Xingqi Guo*, Baohua Xu. Molecular cloning and characterization of two nicotinic acetylcholine receptor β subunit genes from Apis cerana cerana. Archives of Insect Biochemistry and Physiology, 2011, 77(4): 163-178.
30. Feifei Yu, Mingjiang Kang, Fei Meng, Xingqi Guo*, Baohua Xu. Molecular cloning and characterization of a thioredoxin peroxidase gene from Apis cerana cerana. Insect Molecular Biology, 2011, 20(3): 367-378.
31. Fei Meng, Mingjiang Kang, Li Liu, Lu Luo, Baohua Xu, Xingqi Guo*. Characterization of the TAK1 gene in Apis cerana cerana (AccTAK1) and its involvement in the regulation of tissue-specific development. BMB reports, 2011, 44(3): 187-192.
32. Haifang Yang, Mian Wang, Zheng Gao, Changxiang Zhu, Xingqi Guo*. Isolation of a novel RNA-dependent RNA polymerase 6 from Nicotiana glutinosa, NgRDR6, and analysis of its response to biotic and abiotic stresses. Molecular Biology Reports, 2011, 38: 929-937.
33. Ruoyu Guo, Feifei Yu, Zheng Gao, Hailong An, Xuecheng Cao, Xingqi Guo*. GhWRKY3, a novel cotton (Gossypium hirsutum L.) WRKY gene, is involved in diverse stress responses. Molecular Biology Reports, 2011, 38: 49-58.
34. Taobo Ai, Liang Zhang, Zheng Gao, Changxiang Zhu, Xingqi Guo*. Highly efficient virus resistance mediated by artificial microRNAs that target the suppressor of PVX and PVY in plants. Plant Biology, 2011, 13: 304-316.
35. Jing Shi, Hailong An, Liang Zhang, Zheng Gao, Xingqi Guo*. GhMPK7, a novel multiple stress-responsive cotton group C MAPK gene, has a role in broad spectrum disease resistance and plant development. Plant Molecular Biology, 2010, 74: 1-17.
36. Fei Meng, Liang Zhang, Mingjiang Kang, Xingqi Guo*, Baohua Xu. Molecular characterization immunohistochemical localization and expression of a ribosomal protein L17 gene from Apis cerana cerana. Archives of Insect Biochemistry and Physiology, 2010, 75(2): 121-138.
37. Wang Mian, Kang Mingjiang, Xingqi Guo*, Baohua Xu. Identification and characterization of two phospholipid hydroperoxide glutathione peroxidase gene from Apis cerana cerana. Comparative Biochemistry and Physiology, Part C, 2010, 152: 75-83.
38. Ying Zhang, Jing Shi, Yan Liu, Yi Zhang, Jiedao Zhang, Xingqi Guo*. Identification of a novel NPR1-like gene from Nicotiana glutinosa and its role in resistance to fungal, bacterial and viral pathogens. Plant Biology, 2010, 12: 23-34.
39. Yan Liu, Qiouqiang Gao, B Wu, Taobo Ai, Xingqi Guo*. NgRDR1, an RNA-dependent RNA polymerase isolated from Nicotiana glutinosa, was involved in biotic and abiotic stresses. Plant Physiology and Biochemistry, 2009, 47(5): 359-368.
40. Yi Zhang, Dongmei Xi, Jian Wang, D Zhu, Xingqi Guo*. Functional analysis reveals effects of tobacco alternative oxidase gene (NtAOX1a) on regulation of defence responses against abiotic and biotic stress. Bioscience Reports, 2009, 29(6): 375-383.
41. Qiouqiang Gao, Yan Liu, Meimei Wang, Jiedao Zhang, Yingqi Gai, Changxiang Zhu, Xingqi Guo*. Molecular cloning and characterization of an inducible RNA- dependent RNA polymerase gene, GhRdRP, from cotton (Gossypium hirsutum L.). Molecular Biology Reports, 2009, 36(1): 47-56.
42. Fang Li, Yi Zhang, Meimei Wang, Ying Zhang, Xiaoliang Wu, Xingqi Guo*. Molecular cloning and expression characteristics of alternative oxidase gene of cotton (Gossypium hirsutum). Molecular Biology Reports, 2008, 35: 97-105.
43. Xiaoliang Wu, Wencui Hou, Meimei Wang, Fang Li, Jiedao Zhang, Xingqi Guo*. RNA silencing-mediated resistance is related to biotic/abiotic stresses and cellular RdRP expression in transgenic tobacco plants. BMB Reports, 2008, 41(5): 376-381.
44. Jian Wang, Xia Wang, Cheng Liu, Jiedao Zhang, Changxiang Zhu, Xingqi Guo*. The NgAOX1a gene cloned from Nicotiana glutinosa is implicated in response to abiotic and biotic stresses. Bioscience Reports, 2008, 28(5): 259-266.
45. Ying Zhang, Xia Wang, Cheng Cheng, Qiuqiang Gao, Jingyun Liu, Xingqi Guo*. Molecular cloning and characterization of GhNPR1, a gene implicated in pathogen responses from cotton (Gossypium hirsutum L.). Bioscience Reports, 2008, 28(1): 7-14.
46. Meimei Wang, Yi Zhang, Jian Wang, Xiaoliang Wu, Xingqi Guo*. A novel cotton (Gossypium hirsutum L.) MAP kinase gene, GhMAPK1, involved in encountering diverse environmental stresses. Journal of Biochemistry and Molecular Biology, 2007, 3: 325-332.
47. Xia Wang, Yi Zhang, Jiedao Zhang, Cheng Cheng, Xingqi Guo*. Molecular characterization of a transient expression gene encoding 1-aminocyclopropane -1-carboxylate synthase in cotton (Gossypium hirsutum L.). Journal of Biochemistry and Molecular Biology, 2007, 5: 791-800.
