钱建尼原本里刘伟强:北京大学生命科学研究院研究员，青年千人引进人才措。主要从事DNA去架甲基化途径和转座子对附近基因的表达调控研究 。
- 中文名称 钱伟强
- 职业 研究员
- 毕业院校 北京师范大学
- 研究方向 DNA去甲基化途径研究
个人经历
1998 - 2002 ， 理学学士 , 生物学 , 北京师范大学
2002 - 2007，理学博士 , 遗传学 , 中国科学院遗传与发育生物学研究所
2007 - 2009， 博士后 , 遗传学 , 美冷子企干征国康奈尔大学
2009 - 2010 ，博士后 , 遗传学 , 美国加州大学河滨分校
2011 - 2011， 博士后 , 遗传学 , 美国普渡大学
2012 - 2来自013，青年研究员 , 中国科学院上海植物逆境生物学研究中心
2013 - 至今， 研究员 , 北京大学生命科学学院
研究领域
研究背景和方向
以拟南芥为模式系统，360百科研究表观遗传学信息如何影响基因表达以及植物生长发育
主要研究方向
DNA去甲基化途径和转座子对附近基因的表达调控
具体研究内容
DNA甲基化修饰是一种重要的表观遗传学标志，在基因的表达调控，基因组的结构及稳定静占他走识条治控民清依性，X染色体的失活和其它生长发育调控等方面都具有十分重要的作用。DNA波云黄表独管客校额书甲基化的水平主要由甲基化和去甲基化这两个途经来协同调控。在植物体内，DNA去甲基化主要是由repressor of silencing 1 (ROS1)基因家族介导的碱基切除修复机制来实现。早支太差金诉在植物中对DNA甲基化途经的研究已经比较深入居，但是对DNA去甲基化的分机子机制还不清楚。运用遗传学，生物化学和细胞生物学的方法，对植物体内DNA去甲基化的酶学机制以及调控去甲基化的途经进行深入的研究。
参考资料
发表论文
Li Y*, Córdoba-Cañero D*, Qian W*, Zhu X, Tang K, Ariza, R Arjona T and Zhu JK , An AP endonuclease functions in active DNA demethylation and gene imprinting in Arabidopsis , PLo科轻额低任S Genet , 2015 , 来自11(1): e1004905. doi:10.1371/journal.pgen.1004905 (*C离认助晶ontributed e否凯善愿各音之物且东缩qually to this work)
Duan C, Zhang H, Tang K零慢拿需, Zhu X, Qian W, Hou Y, Wang B, Lang Z, Zhao Y, Wang X, Wang P, Zhou J, 于路兰镇端油均容独故Liang G, Liu N, Wang C, Zhu JK , Specific but interdependent functions for Arabi360百科dopsis AGO4 and A落现决见右电灯批找乱即GO6 in RNA-d燃还鲜irected DNA methylation , EMBO J , 2014 , pii: e201489453
Qian W*, Miki D*, Lei M*, Zh突掉兵那兵件量完汉送含u X, Zhang H, Liu Y, Li Y, Lang Z, Wang J, Tang K, Liu R and Zhu JK. , Regulation 调以气阳of Active DNA Demethylation by an α-Crystallin Domain Protein in Arabidopsis , Mol Cell , 2014 , 55(3):361-71(*Contributed equally to this work)
Zhang H, Tang K, Qian W, Duan CG, Wang B, Zhang H, Wang P, Zhu X, Lang Z, Yang Y and Zhu 少演JK , An Rrp6-l影同司货服转煤早除女大ike protein positively regulates noncod移房著强局ing RNA levels and DNA methylation in Arabidopsis , Mol Cell , 2014 , 8;54(3):418-30
Li X, Qian W, Zh温岩科形ao Y, Wang C, Shen J, Zhu J-侵米山K and Gong Z , The anti-Silenci除流容ng role of the RNA-directed DNA methylation pathway and a histone acet翻训洋史沿做沉yltransferase in Arabidopsis , Proc Natl Acad Sci U S A , 2012 , 109(28):11425-30
Qian W*, Miki D*, Zhang H, Liu Y, Zhang X, Tang K, Kan Y, La H操别盐带养失司防初通, Li X, Li S, Zhu X, Shi X, Zhang K, P养景推音克月这等八ontes O, Chen X, Liu R, Gong Z and Zhu JK , A Histone Acetyltransferase Regulates Active DNA Demethylation in Arabidopsis , Science , 2012 , 336(6087):1445-8
Mang HG*, Qian W*, Zhu Y, Qian J, Kang HG, F.Klessig D and Hua J , ABA deficiency antagonizes high temperature inhibition of disease resistance through enhancing nuclear accumulation of resistance proteins SNC1 and RPS4 in Arabidopsis , Plant Cell , 2012 , 24 (3): 1271-84,*Contributed equally to this work
Martínez-Macías M*, Qian W*, Miki D*, Pontes O, Liu Y, Tang K, Liu R, Morales-Ruiz T, R. Ariza R, Roldán-Arjona R, and Zhu JK , A DNA 3'-phosphatase functions in active DNA demethylation in Arabidopsis , Mol Cell , 2012 , 45(3): 357-70,*Contributed equally to this work
Wang L*, Li Z*, Qian W, Guo W, Gao X, Huang L, Wang H, Zhu H, Wu JW, Wang D and Liu D , Arabidopsis purple acid phosphatase AtPAP10 is predominantly associated with the root surface and play an important role in plant tolerance to phosphate limitation , Plant Physiol , 2011 , 157 (3): 1283-99
Tran HT, Qian W, Hurley BA, She YM, Wang D, and Plaxton WC , Biochemical and molecular characterization of AtPAP12 and AtPAP26: the predominant purple acid phosphatase isozymes secreted by phosphate-starved Arabidopsis thaliana , Plant Cell Environ , 2010 , 33 (11): 1789-803
Gao Z, Liu HL, Daxinger L, Pontes O, He X, Qian W, Lin H, Xie M, Lorkovic ZJ, Zhang S, Miki D, Zhan X, Pontier D, Lagrange T, Jin H, Matzke AJ, Matzke M, Pikaard CS and Zhu JK , An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation , Nature , 2010 , 6;465(7294):106-9
Zhu Y, Qian W, and Hua J , Temperature modulates plant defense responses through NB-LRR proteins , PLoS Pathog , 2010 , 1;6 (4):e1000844
Qin C, Qian W, Wang W, Wu Y, Yu C, Jiang X, Wang D, Wu P , GDP-mannosepyrophosphorylase is a genetic determinant of ammonium sensitivity in Arabidopsis thaliana , Proc Natl Acad Sci USA , 2008 , 25;105(47):18308-13
Liu X*，Qian W*, Liu X, Qin H, and Wang D , Molecular and functional analysis of hypoxanthine-guanine phosphoribosyltransferase from Arabidopsis thaliana , New Phytol , 2007 , 175(3):448-61,* Contributed equally to this work
Qian W, Yu C, Qin H, Liu X, Zhang A, Johansen, I.E, and Wang D , Molecular and functional analysis of phosphomannomutase (PMM) from higher plants and genetic evidence for the involvement of PMM in ascorbic acid biosynthesis in Arabidopsis and Nicotiana benthamiana , Plant J , 2007 , 49(3):399-413
参考文献
